22_Hornet is about the smallest caliber I have seen for PA rifle deer hunting season. I wouldn't shoot at deer, I would start out with a .25" rifle calibers, 250 Savage or 257 Roberts. I know people are gonna say 243 will kill, my boy/girl uses it just fine. Go right ahead, but I think the 243/6mm is too small. Coyote, yes. Deer, no. This is just my observation from years ago. I shot deer with my 243 (either shoulder or behind the shoulder) and they ran 75 - 125 yards before the deer gave up the ghost. One doe ran 325ish yards using the 85gr Barnes X bullet. It didn't open up, just poked a small hole thru the lungs. It was the day I gave up on the 243. My friend uses the 243 religiously for 40+ years. He finds a cheap 100gr factory load locally and he goes hunting. Behind the shoulder, about a 1/3 of the way up is where he aims and I swear to Christ above, its either dead right there or it will stumble about 5 feet and die. One buck got away when he aimed at the head. The buck was found by cousin a couple of days later and it was still alive. Turns out, that my friend shot it thru jaw. It was the last time he shot it thru the head. Must of been 35+/- years ago.