After my first sit in the stand. I realized that a shot to my far right would be difficult. I practiced the next day shooting left handed to see if POI changed or there were any issues. I ound that I could do it if needed.
The one buck I shot a few years back was with my opposite side. He was close and came in from behind me and I couldn't move a lot, thankfully it worked out. I don't practice shooting opposite a lot but growing up left handed doing things right handed doesn't feel that uncomfortable. I don't think I would want to take a far shot unless I did more practicing.
Sure it can be done..i shoot both left and right...my brother inlaw lost his eye sight in his right eye 3 years and has shot left handed and has killed 2 bucks the last two seasons....he killed one this morning also...so it just takes alot of practice...but it can be done...
I'm right-handed but learned to shoot rifle, pistol, or shotgun with either hand as a kid. My dad was left handed. I prefer to shoot left-handed even though I'm right-eye dominant. Most of my guns have a tang safety that I can use comfortably with either hand. IMHO it's a huge advantage to be able to switch the gun to the other hand when needed for a shot. It's worked for me on several occasions for turkey, deer, and predators. If you are naturally RH'd, it's not that hard to shoot LH'd because you have more strength and dexterity in you right hand to hold and maneuver the gun or crossbow.