I think you are looking for an answer that doesn’t exist.
No two guys are the same, and different guns carry better one way than the other.
It took me many years and several holsters in different designs to come up with what was best for me. Bottom line, if the holster is inconvenient or uncomfortable you will not wear it.
For me, I never wear a concealment garment. By that I mean I never wear a vest, wind breakers, long sleeve dress shirt, etc. I'm normally in shorts and an under armour t-shirt in the spring/summer. So for me having the semi in a holster with cant helps me hid the gun better. My Glocks have a large fat grip and having it ride that way makes less of the grip stick out from behind me. If I were to use a straight drop the grip would be exposed more. You really just have to try different setups to get the gist. I wear mine about 4:00.
Slight cant on my paddle holster. It keeps the handle butt from poking through and imprinting the back of my shirt when I lean over. I use a DeSantis Top Cop paddle holster that rides high so I need a little cant.