I guess I've owned about every domestic model .250 made....down to a pair of 99Fs and a 700 Classic now....killed a few deer with 100 gr. handloads and all died very quickly....
Older 99s, pre 64 70s and the 1920 Savage bolt action have 1-14 twists which often do not like bullets heavier than 87 grains which will usually not stabilize in that twist.
A pioneer BR shooter & gunsmith from Oil City, Pa, Frank Riddle, counted the .250 as his favorite and killed a bunch of deer and one black bear with the 87 gr. bullet. He also built some dandy ultra-lightweight .250s on 98 Mausers that shot like a house afire....
It's a great little cartridge, IMO....