Nothing lives with a hole in the heart or lungs.No matter what caliber or grain bullet.It up to the shooter to know his own limits and abilities more than the limits of the caliber.
Federal has plenty of choices. (Filter on .223 or 22-250 and medium game) Finding them in stock could be a challenge. Ammoseek.com is your friend.I've been thinking about this myself lately. My 22-250 shoots 55 gr VMaxs really well, but I know I don't want to try them on deer - my issue has been finding 22 caliber interbonds, accubonds, gmx, partitions, or anything else that would be an acceptable deer bullet.
Look at a company called Hammer Bullets, I have been using their bullets in my 6.5 PRC and I have to admit they have worked exceedingly well on game so far.I've been thinking about this myself lately. My 22-250 shoots 55 gr VMaxs really well, but I know I don't want to try them on deer - my issue has been finding 22 caliber interbonds, accubonds, gmx, partitions, or anything else that would be an acceptable deer bullet.