I hunt with a Ruger Super Redhawk and a TC Contender. The S.Redhawk is in 44 mag with a 9 inch barrel. I had a scope on it for a while, but recently took it off as it is my dedicated bear driving gun. My Contender is also a 44 mag (I have other barrels too). This set up is a little more unique. I have a TC custom shop hunter special barrel. The barrel is a 12in with a brake at the end and a burris 2x scope.
As far as hunting with a pistol I'd say practice! It's not like your rifle or slug guns or any long arm for that matter. Your target acquisition is not as fast (unless you use open sights). So take you time and ready your shot. Additionally, unless you practice a lot your pull will be different shooting double action. Even when I fire at a bear I'm working my S.Redhawk as a single action for better accuracy. Their is much less trigger pull on single action.
I agree with what others have said. Your biggest challenge will be finding a steady rest. You can shoot them off hand, but it is a lot more difficult. I now use a primos mono pod that can extend up to my chest. It had a rubber V on the top which makes for a great rest. Other than having a sturdy rest will be a quality holster. Don't cheap out on a good shoulder holster. Most hunting hand cannon tend to be heavy. You'll want the safety, security, and readiness of a quality holster.