When I shot PBs out of my .50 Renegade and .50 Lyman, I shot them over 85 grains of FFFg black powder. Very accurate out of both guns at 50 yards; never really shot them on paper much farther than that as I was young and didn't expect to take a great number of long-distance shots. I'm sure there are those out there who have much more experience with them than I do. I decided after my first round of PBs were used up that I was just going to stick with PRBs. So much cheaper, and every deer that I have shot with them (at least every one that has found its mark) has dropped just as dead as with the PBs. I will say this: the only deer I ever shot with one dropped instantly from a neck shot (bad shot placement on my part, I think I flinched the shot). It was... devastating over that 85 grains of powder. They hit hard and shoot well, just a bit outside the price range I want to spend on them. They certainly have the advantage of being easier to load quickly than round balls; again, an opinion.
A bad day hunting rabbits beats a good day of anything else!