It all depends on what you want to do.The only thing the 2 have in common is that they are both rimfires.For squirells the .22 is better cause it won,t cause much damage to meat.But for hogs,coyotes and such the .17 wins hands down.It literely explodes when it penetrates.
Yes a ,22 hollow point is better but it still don,t have the destructive capability of a .17HMR.I have never not shot a hog that it didn,t fall right over and look like it was clobbered with a hi-power centerfire.
do not waste your time with a 22lr or a 17 rimfire for coyotes or even fox...do yourself and the critters were hunting a favor and buy a 22hornet or a 17 fireball or 17rem....those 3 calibers are fur friendly almost all the time and will anchor a yote yet not blow apart a fox...
The HMR will ruin a squirrel unless you shoot it in the head. For woodchucks, I only shot 2 with my HMR when I had it. With the 20gr load in the head. Both were lights out. As for coyotes I wouldn't even think about using the .22 or the .17HMR, unless you don't care about wounding or never finding some.
Wrong,I,ve done wasted to many critters with one shot with the .17HMR to let this go without comment.Plus the ammo is cheap.Ihave shot hundreds of varmints with my .17 and I don,t remember needin more than 1 shot to do the job.