Just don't use a 22 on skunks.
In the late 1950s/early 1960s I trapped a lot of skunks while in school. Most of those years a good #1 or even #2 skunk was worth 2 muskrats.
I checked my traps before school and my skunks were shot with a .22.
An older boy showed me the best way to shoot a trapped skunk. The first thing walk right up to the skunk, rifle or revolver at the ready. Do not shoot from 20-30 feet away. 8-10 feet is about right. Unless you have a yapping dog dancing about or some fool kid shouting and skipping about you are not going to trigger the spray response in the skunk.
Now we have established you have to get into a range where where you are going to score a guaranteed hit on 1 shot.
Now for the easy part. Just cooly and calmly fire 1 round into the skunk's head. 1 [one]. No more. Use a .22 short cartridge. Then turn around and walk away. Turn and walk. Go check your remaining traps.
Do not worry what the skunk is doing after you fire the shot. Most likely it's going to be standing there watching you. That's fine. The skunk is not going home with us right now any way.
Just leave him alone and don't bother him with additional shots or poking sticks unless you want a stinky mess.
While in school, skunks shot in the morning were left to quietly expire during the day, then collected in the afternoon.
When I was older and I had to jiggle a job, I would leave the skunk till the next day.
When handled this way, skunks usually just lay down, curl up and pass. You find them in full rigor mortis the next trip through. Seldom do they spray, and even if they do it is just a few drops, not full blown sac emptying blasts. Leaving them out over night helps the critter to 'blow off.'