I would look at the big picture. Where the stream travels to & from. Is there food available. Typically these stream are Mink travel ways. Depends on food how much time they spend here or are Mink just passing thru. But I can say that about any small stream in southern Pa. or northern Pa is a Mink travel way.
I know they have lots of little native brook trout, squirrels and rodents in and around them.
During Mink season, many rodents are underground. You may have better success trapping lower on the mountain, where there is more food.
is it worth a shot setting for them on the Mountain Streams?
Hard to say from this desk chair. I know this is a fast pace world and we want quick answers and results. But trapping doesn't work that way in most cases. Some things are trail & error, even today.
My answer is Yes, give it a shot. See for yourself. If small mountain streams are what you got, play the cards dealt to you.
I would like to point out many northeastern USA mink trappers work on small mountain streams & have success. Learning about the Mink and having a stable population will aid in your success.