I might get roasted a little for this opinion, but here we go:
Dollar for Dollar, you really can't beat Hornady XTPs in 250 or 300gr and some Harvester sabots. Bought in bulk, you can get to about 35 cents (sometimes less) per shot plus powder & primer.
I have an Optima V2 that shoots the .430 300gr and .452 300gr XTPs equally well, pushed by 100gr 777 (pellets). Since they group the same, I decided on the .430 for the ever-so-slightly flatter trajectory and higher sectional density. (Deeper penetration).
Have yet to have a deer go more than 20 yards, most drop within feet of impact. Could drop them all in the tracks if I felt like a high-shoulder shot, but I don't like wasting meat.
Not knocking Barnes at all, they're great bullets and have a proven track record. But like many of the "specialty" or blister-pack bullets out there, the $1+/bullet cost just isn't justified to me...
Ultimately, you'll be best served by trying a few different bullets and powders, see what your gun likes, then choose what meets your tastes/needs.
Lastly, if you feel the need to try out PowerBelts, don't touch any less than the 295gr offerings in the "Copper" line. The Aerolites and Platinum lines are decent, but with any PowerBelt, you're back over $1/bullet unless you find a screaming bulk deal. They sure do shoot nice, but are WAY overpriced and when pushed too fast (Copper series at least), have mediocre to poor performance.