The Mississippi is a natural barrier, not saying a deer can not cross it, but it would not be a common thing. To kill the deer off in just the diseased areas would not work well, as you said deer would still travel in and out of the infected area. You would need a kill off in a buffer zone. And this is not something that normal hunting could accomplish. It would need to be done by killing, no bag limit, killing at any hour, using dogs, using bait, anything goes. As I am saying this would not be hunting but killing, to try to deplete an area of all deer, a hard task. Not everybody would want such a thing, but it may greatly slow the spread. However one buzzard, hawk, or eagle could feed on an infected deer and then fly off, and thru its droppings, spread CWD to an area many miles away. So another thing would be to try to reduce these scavengers in CWD areas. This will not happen. Deer farms brought CWD here, but once in the wild herd, it will keep spreading, because man will not do all the things required to help slow its spread. All regulations ,will for the most part, be aimed at limiting mans actions that may spread it, such as the one already in place. No urine while hunting in certain areas, not moving some of the infected parts, but as for the scavengers and deer themselves spreading it, this will not be addressed in a manner that will greatly reduce or slow the spread. My opinion is that all animals that can spread CWD should try to be removed from an infected area and a buffer zone. And then the area should be kept as a dead zone. This would have been an easier task before it has spread to such a large area. All the regulations that have been put on hunters, has not done much to stop the spread. And I do not believe that any radical approach, that may help, will come anytime soon.