I ran my 223 load through the Hornady after I changed scopes from a mils to a open sight A4 rear sight assembly for a open sight match to a MOA graduated scope and only had a hour to fire at 3 and 600 before a match, it was close. My buddy who did caribou this summer used it on a 06 and it was close enough at 2-3 and 400 to be better than minute of critter.
Use advanced, make sure you have the right type bullet (G7 EG) entered, take a pretty good swag at the humidity, elevation and temp and then test it on the range. There is enough difference in real flight vs computed flight that they should only be used to get you close on paper. I wouldnt hunt without at least verifying it at the range that I was going to hunt but it should get you in the ball park. Is your velocity measured with a chrony or factory stamped on the box? If they test with a 24" accuracy bbl and you are using a 18" light sporter, you are not going to get the same velocity. The better the input, the closer the compuguesser is.
Every day you see it on the news. Another felons life needlessly spared by inaccurate fire.